Human monoclonal antibodies with great neutralizing properties against BK virus. BKV infection causes BKV-associated nephropathy (BKVAN) in kidney transplant recipients, which leads to graft loss or urothelial carcinoma, but can also lead to hemorrhagic cystitis in bone marrow transplant recipients. Our lead antibodies have the ability to be best in class and neutralize BKV with improved efficacy

New target and approach for the treatment of melanoma. Our technology aims at decreasing the expression of a novel long non-coding RNA that has been shown to be essential for the survival and proliferation of melanoma cancer cells using antisense oligonucleotides.

Light-Up Nucleic Acid technology based on a light-up RNA aptamer able to specifically recognize a fluorogen and light up a fluorescence signal.
Module with very good properties in term of brightness, photostability and signal to noise ratio. Could overcome current limitations of RNA imaging and could be applied in diagnostic to detect RNA targets with high specificity and sensibility.

A new resorbable guide for nerve repair to facilitate certain microsurgical operations.

Near-Infrared Coating of Equipment: Fluorescent coating technology of surgical devices with application to Fluorescence Image Guided Surgery. Improves endoscopic procedures thanks to better visualization modalities. FDA approved polymer and original fluorescent dyes with better properties than standards; can be applied to various substrates. A start-up company will be created to develop this tech.

Development of a micro-fabricated plate system that allows for the production of organoids that are reproducible in shape and size

First-in-class non peptidergic agonist of oxytocin receptor, with improved activity over endogenous oxytocin, for treatment of social interaction impairments in autism spectrum disorders (ASD)
In vivo preclinical PoC data package: Restore social interaction in ASD mouse model, good safety profile, oral administration

Medical simulation software and environment bringing almost real conditions of surgery, including supervisor's evaluations, immersive images and sounds, ground sensors, heart rate sensors, cameras etc.

The sliding β-clamp, a ring shaped dimer that encircles dsDNA, and the protein-protein interactions in bacterial replication are entirely conserved and represents an attractive target for the design of new antibiotics. This project aims at developing, optimizing, and evaluating a series of 5 aa residues peptides targeting the sliding β-clamp in an in-vivo model of gram-negative infection.

New Chemical Entity with neutraligand activity on CXCL12
New way to modulate Immune response and inflammation in various clinical settings, including auto-immune diseases and inflammatory pain. 
Sub-micromolar affinity, promising in-vitro ADME parameters and oral bioavailability.