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Dental implants with improved osteointegration

This project is managed by Adèle Carrado and Geneviève Pourroy from the IPCMS. It consists in a successive covering method of a titanium surface by sodium titanate then calcium phosphate applied to dental implants.

Dental implants allow replacing dental deficiencies of the patient due to accidents, cavities and other weakness related to the age. The implant is introduced in the patient’s jaw and requires integration time to bony tissue prior the veneering ceramic addition. High purity titanium (Ti) is the privileged material for dental implants due to its moderate cost and its excellent compatibility with the organism. Nevertheless osteointegration can be long and uncomfortable for some patients and can sometimes prompt the implant reject.


The developed technology of this project allows moving beyond these drawbacks. The surface of titanium is indeed partly oxidized before being recovered by Ca-P through soaking or spin coating and two stages of thermic treatment allow strengthening the adhesion of hydroxyapatite on titanium. Therefore the new surface possesses the following advantages:

  • A better adhesion of the Ca-P layer to titanium
  • Alveolar morphology of the sediment close to bone structure


These characteristics obtained thanks to the proposed process allow a better osteointegration of the implanted material with bony tissues. Moreover proposed stage sequence presents other attractive features in its application:

  • Implant not degraded by the fabrication process (no micro crack)
  • Simple fabrication process requiring only soaking containers and a kiln
  • Possibility to control the thickness of the Ca-P layer (modularity)


Thanks to the investment fund in innovative project maturation from Conectus Alsace, the research team will be able to realize test on test-pieces treated with this process in order to check that it does not weaken the material. In the second phase, they will achieve in vitro and in vivo tests on a reference implant submitted to the said process in order to measure cellular growth and realize then implantology tests on animal subjects.


Investment: 297 000€ over a period of 18 months